Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2016, Vol. 38 ›› Issue (5): 534-538.doi: 10.3881/j.issn.1000-503X.2016.05.007

• Orginal Article • Previous Articles     Next Articles

Clinical Features of Pituitary Stalk Interruption Syndrome in 114 Cases

Bai-yu HAN1,2, Qian ZHANG1,3, Le-le LI1, Qing-hua GUO1, Cheng-zhi WANG1, Li ZANG1, Nan JIN1, Fang CHEN1, Ling ZHAO1, Jia CUI1, Xiu-lian GU1, Fang-ling MA1, Sai-chun ZHANG1, Yi-ming MU1, Jing-tao DOU1()   

  1. 1Department of Endocrinology,Chinese PLA General Hospital,Beijing 100853,China
    2Department of Endocrinology,the 264th Hospital of PLA,Taiyuan 030001,China
    3Department of Endocrinology,PLA Army General Hospital,Beijing 100700,China
  • Received:2015-09-21 Online:2016-10-20 Published:2016-10-10
  • Supported by:
    Supported by the National Natural Sciences Foundation of China (81370871)

Abstract:

Objective To analyze the clinical characteristics of pituitary stalk interruption syndrome(PSIS). Methods The clinical data including clinical manifestations,laboratory tests,and imaging findings of 114 PSIS patients in our hospital were retrospectively analyzed. Results Of these 114 PSIS patients,102 cases (89.4%) were male. The average age was 21.1±6.1 years. A history of breech delivery was documented in 91 cases (91.9%). Short stature was found in 89 cases (71.8%) and bone age delayed (6.1±5.1) years. Secondary sex characteristics were poor or undeveloped in most patients. The prevalence of deficiencies in growth hormone,gonadotropins,corticotropin,and thyrotropin were 100.0%,94.0%,84.2%,and 74.6%,respectively. Hyperprolactinemia was found in 28.1% of patients. Three or more pituitary hormone abnormalities were found in 105 cases(92.1%). Compared with the 5 cases with history of cephalic delivery,no difference were found in the aspects of height(t=0.297,P=0.634),penile length(t=1.205,P=0.882),testicular volume (U=99.000,P=0.348),growth hormone peak (U=89.000,P=0.186),adrenocorticotropic hormone peak(U=131.000,P=0.967),luteinizing hormone peak(U=98.500,P=0.582),thyroid-stimulating hormone (U=82.000,P=0.162),and the height of anterior pituitary (t=1.676,P=0.107) in the 53 cases with history of breech delivery. Conclusions The clinical manifestations,symptoms,hormone deficiencies were severe in our series. The condition severities were not remarkably different in patients with different delivery ways.

Key words: pituitary stalk interruption syndrome, clinical characteristics, hypopituitarism

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