Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2016, Vol. 38 ›› Issue (5): 583-588.doi: 10.3881/j.issn.1000-503X.2016.05.017

• Orginal Article • Previous Articles     Next Articles

Research Advances in the Mutation of TET2 Gene in Myeloid Maligancies

Rong LI, Ming-jiang XU, Feng-chun YANG, Yuan ZHOU()   

  1. State Key Laboratory of Experimental Hematology,Institute of Hematology and Blood Disease Hospital,CAMS and PUMC,Tianjin 300020,China
  • Received:2015-09-08 Online:2016-10-20 Published:2016-10-10
  • Supported by:
    Supported by the National Nature Sciences Foundation of China(81328003)and the Major Program of Applied Basic Research Foundation of Tianjin (13JCZDJC31200)

Abstract:

TET2 gene is a member of TET oncogene family. It has been reported as a tumor suppressor gene with important roles in myelopiesis. Recent studies have shown that TET2 protein takes part in demethylation by converting 5-methylcytosine (5-mc) into 5-hydroxymethylcytosine (5-hmc). Somatic TET2 inactivation leads to abnormal myelopiesis and myeloid malignancies. In this review,the structure and function of TET2 and the relationship between TET gene mutation and myeloid malignancies are summarized.

Key words: TET2, mutation, myeloid malignancies

CLC Number: