Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2017, Vol. 39 ›› Issue (1): 128-132.doi: 10.3881/j.issn.1000-503X.2017.01.021

• Orginal Article • Previous Articles     Next Articles

Expressions of Immune Negative Regulator FoxP3+Treg and PD-L1 Protein in the Immune Microenvironment of Cervical Lesion

Qian MA1, Minyi ZHAO2, Xing WEI2, Juan ZHAO2, Ting YANG2, Qian ZHANG2, Kai WANG3, Xiaofeng YANG2()   

  1. 1Department of Gynecology,Yan’an Hospital Affiliated to Kunming Medical University,Kunming 650051,China;
    2Department of Obstetrics and Gynecology,3Department of Pathology,the First Affiliated Hospital,Xi’an Jiaotong University,Xi’an 710061,China;
  • Received:2016-09-18 Online:2017-02-10 Published:2017-02-20
  • Supported by:
    Supported by the National Natural Sciences Foundation of China (81072145) and the Program for New Century Excellent Talents in University (NCET-12-0441)

Abstract:

Objective To explore the expression patterns of immune negative regulator FoxP3+Treg and PD-L1 protein in cervical carcinoma and its precancerous lesions. Methods The expression patterns of FoxP3+Treg and PD-L1 protein in 45 cases of cervical lesions tissues of the cervix and 20 cases of normal cervix tissues by using immunohistochemistry (IHC). Results Compared with the normal cervix,the expressions of FoxP3+Treg (H=43.211,P=0.000) and PD-L1 protein (t=213.00,P=0.001) were significantly increased in cervical lesions. Compared with the low-grade squamous cell carcinoma,the invasiveness of FoxP3+Treg was increased in high-grade squamous cell carcinoma (H=28.307,P=0.000),along with increased expression of PD-L1 protein (t=239.000,P=0.028). The FoxP3+Treg expression was positively correlated with PD-L1 protein expression in abnormally differentiated cells (rs=0.364,P=0.003). Conclusion Along with the progression of cervical cancer,the FoxP3+Treg amount increases in the local microenvironment,along with enhanced PD-L1 protein expression in abnormally differentiated cells.

Key words: cervical cancer, immune microenvironment, FoxP3, Treg, PD-L1

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