Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2017, Vol. 39 ›› Issue (2): 163-168.doi: 10.3881/j.issn.1000-503X.2017.02.001

• Orginal Article •     Next Articles

Synthesis and Characterization of Polyamidoamine Dendrimers/Nano-hydroxyapatite and Its Role in Dentin Tubule Occlusion

Xuandong LIN, Fangfang XIE(), Yuhong HAO, Hejia QIN, Jindong LONG   

  1. Department of Endodontics,Affiliated Stomatological Hospital of Guangxi Medical University,Nanning 530021,China
  • Received:2016-09-28 Online:2017-04-20 Published:2017-04-20

Abstract:

Objective To synthesis and characterization nano-composite biomaterials-polyamidoamine dendrimers/nano-hydroxyapatite (PAMAM/n-HAP),which has the properties of both organic and inorganic materials,and then evaluate its role in dentin tubule occlusion. Methods PAMAM/n-HAP was characterized and validated by Fourier transform infrared spectrometry and transmission electron microscopy after its preparation via the Pramanik aqueous-based chemical method. Scanning electron microscope was used to evaluate its role in dentin tublule occlusion. Results The peak absorption bands were found at 1244 cm-1 and 1650 cm-1 in Fourier transform infrared spectroscopy. A relatively low-density coating (about 10 nm) appeared on the n-HAP. The results of Fourier transform infrared spectrometry and transmission electron microscopy confirmed the successful synthesis of PAMAM/n-HAP. The scanning electron microscope showed that PAMAM/n-HAP could effectively reduce the diameter of the dentin tubule and close dentin tubule. Conclusion PAMAM/n-HAP,as a newly synthesized biomaterial,has a good binding capacity with collagen fibers with the help of superficial carboxyl. It can induce effective dentinal tubule occlusion,indicating that PAMAM/n-HAP have great potential in clinical practice for dentin hypersensitivity.

Key words: polyamidoamine dendrimers/nano-hydroxyapatite, dentin hypersensitivity, dentin tubule

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