Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2017, Vol. 39 ›› Issue (2): 188-195.doi: 10.3881/j.issn.1000-503X.2017.02.005

• Orginal Article • Previous Articles     Next Articles

Change of Serum Angiopoietin-like Protein 2 and Its Significance in Patients with Arteriosclerotic Occlusion

Yue LIANG1,2, Hao NIE1, Hualiang REN3, Fangda LI1, Cui TIAN4, Huihua LI5,6, Yuehong ZHENG1()   

  1. 1Department of Vascular Surgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China
    2Department of Vascular Surgery,Inner Mongolia People’s Hospital,Inner Mongolia 010017,China;
    3Department of Vascular Surgery,Chaoyang Hospital of Beijing Affiliated to Capital Medical University,Beijing 100020,China
    4Department of Physiology and Physiopathology,Capital Medical University,Beijing 100069,China
    5Department of Cardiology,Institute of Cardiovascular Diseases,First Affiliated Hospital of Dalian Medical University,Dalian,Liaoning 116011,China
    6Center for Prevention and Control of Non-communicable Chronic Diseases,School of Public Health,Dalian Medical University,Dalian,Liaoning 116044,China
  • Received:2016-03-04 Online:2017-04-20 Published:2017-04-20
  • Supported by:
    Supported by the National Natural Sciences Foundation of China (81270390)


Objective To investigated the changes of angiopoietin-like protein 2(Angptl2) in patients with arteriosclerotic occlusion (ASO). Methods A total of 140 subjects including 75 ASO patients (ASO group) and 65 healthy subjects (control group) were enrolled in this study. Angptl2 and adiponectin were evaluated by using enzyme-linked immunosorbent assay. Biochemical data and high sensitive C reactive protein were measured and recorded as well. Results Compared to the control group,the ASO group presented with significantly higher level of plasma Angptl2 [(13.55±9.17) μg/L vs. (9.04±4.79) μg/L,P=0.010]. Plasma Angptl2 level of critical limb ischemia subjects was significantly higher than that of intermittent claudication subjects [(17.01±10.20)μg/L vs. (10.53±6.97) μg/L,P=0.003]. The best diagnostic cutoff value of Angptl2 was 13.67 μg/L,with a sensitivity of 60.34% and a specificity of 81.25%. In addition,type 2 diabetes mellitus patients with ASO exhibited significantly higher serum Angptl2 levels [(18.67±9.84)μg/L] than those without ASO [(13.01±3.47) μg/L] (P=0.021). In ASO group,serum Angptl2 levels were negatively correlated with ankle brachial index (r=-0.244,P=0.035). Conclusion The plasma level of Angptl2 increases in ASO patients. Its level is remarkably increased when the disease progressions to critical limb ischemia. Angptl2 can be a potential biological marker of disease progression.

Key words: arteriosclerotic occlusion, angiopoietin-like protein 2, intermittent claudication, critical limb ischemia, diagnosis, clinical significance

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