Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2017, Vol. 39 ›› Issue (2): 206-210.doi: 10.3881/j.issn.1000-503X.2017.02.007

• Orginal Article • Previous Articles     Next Articles

Clinical Analysis of 122 Cases of Langerhans Cell Histiocytosis

Tao WANG1, Beibei SU1,2, Dawei HAN1, Anli TONG3, Jian LI4, Yuehua LIU1(), Hongzhong JIN1, Kai FANG1   

  1. 1Department of Dermatology,3 Department of Endocrinology,4 Department of Hematology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China
    2Department of Dermatology,Xinxiang Central Hospital,Xinxiang,Henan 453000,China
  • Received:2016-08-13 Online:2017-04-20 Published:2017-04-20

Abstract:

Objective To investigate the features of Langerhans cell histiocytosis (LCH). Method Skin lesions,systemic involvement,imaging characteristics,laboratory tests,immunophenotying,treatment response,and survival of 122 LCH patients treated at our center from February 1983 to August 2013 were retrospectively analyzed. Results LCH was associated with diverse skin lesions. Lung was the most involved organ,followed by bone,skin,lymph nodes,liver,spleen,oral cavity,and thyroid. Multisystem LCH was more common than single-system LCH. Single-system LCH was mostly treated by surgery,whereas multisystem LCH by combined chemotherapy. Conclusion LCH has diverse clinical manifestations,with lungs being the most often involved organ. Surgery or chemotherapy is the mainstream treatment.

Key words: Langerhans cell histiocytosis, clinical analysis, retrospective, treatment

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