Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2017, Vol. 39 ›› Issue (2): 290-295.doi: 10.3881/j.issn.1000-503X.2017.02.021

• Orginal Article • Previous Articles     Next Articles

Advances in Diagnosis and Management of Mitochondrial Cardiomyopathy

Ruiqi ZHUGE, Rong ZHOU, Xinhai NI()   

  1. Department of Cardiology,Fuwai Hospital,National Center for Cardiovascular Disease,CAMS and PUMC,Beijing 100037,China
  • Received:2016-01-04 Online:2017-04-20 Published:2017-04-20


Mitochondrial cardiomyopathy (MCM) is a series of myocardial conditions characterized by abnormal heart-muscle structure,function,or both,secondary to genetic defects involving the mitochondrial respiratory chain,in the absence of concomitant coronary artery disease,hypertension,valvular disease,or congenital heart disease. MCM patients typically have hypertrophic or dilated cardiomyopathy. Arrhythmias and left ventricular myocardial noncompaction are less common,and heart failure may occur as the first symptom in some patients. Since MCM patients often have symptoms of multiple organ involvement,the symptoms are not specific and the diagnosis can be difficult. Thus,awareness of this disease must be increased in clinical settings. Treatments for MCM are mostly supportive and nonspecific. In this review,we summarize new advances in the diagnosis and management of MCM,with an improve the clinical management of this disease.

Key words: mitochondria, mitochondrial cardiomyopathy, diagnosis, management

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