Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2017, Vol. 39 ›› Issue (4): 485-491.doi: 10.3881/j.issn.1000-503X.2017.04.005

• Orginal Article • Previous Articles     Next Articles

Effectiveness of Peritoneal Dialysis in Treating Adult End Stage Renal Disease Patients with Polycystic Kidney Disease

Ying MA, Haiyun WANG, Zijuan ZHOU, Yang LI, Wei YANG, Bingyan LIU, Jinghua XIA, Xuemei LI, Limeng CHEN   

  1. Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China
  • Received:2016-07-13 Online:2017-08-10 Published:2017-08-20
  • Supported by:
    Supported by the Sub-project Founded by Ministry of Science and Technology of China(2012CB517803)and National Natural Sciences Foundation of China(81470937)

Abstract: Objective

To observe the clinical characteristics,dialysis modalities,and outcomes of end stage renal disease(ESRD)patients with polycystic kidney disease(PKD)and to evaluate the feasibility of peritoneal dialysis in these population.

Methods

The clinical data of ESRD patient whose primary diagnosis was PKD in Peking Union Medical College Hospital were retrospectively collected from January 1993 to December 2015.PKD patients were divided into two groups according to dialysis modality,namely peritoneal dialysis group(PKD-PD)group and hemodialysis(PKD-HD)group.In addition,we randomly chose non-PKD patients from 622 peritoneal dialysis patients who were matched with PKD-PD patients in age,gender and dialysis time.The primary end point was death.The survival rate was calculated by Kaplan-Meier analysis and the risk factors for suivival were analyzed by Cox regression model.

Results

Totally 47 PKD patients were enrolled,including 33 patients in PKD-PD group and 14 patients in PKD-HD group,and 42 non-PKD patients as the control group.The average age of PKD patients was(53±11)years,of which 38.3% were women.When compared with PKD-HD group,no significant difference in age,gender,comorbidities,kidney size,and residual glomerular filtration rate were observed in PKD-PD patients at baseline(all P>0.05).The average time on dialysis of PKD-PD patients was(36.2±33.1)months.The weekly urea clearance index(Kt/V)and weekly creatinine clearance were similar to non-PKD-PD group at 3 months,1 year,3 years,and 5 years(all P>0.05).The peritonitis rate was 1 episode/84.5 months.The survival rates at 1 year,3 years,and 5 years of PKD-PD group were 85.7%,78.6%,and 78.6%,which were similar to non-PKD-PD group and PKD-HD group respectively(all P>0.05).Multivariate Cox regression analysis showed that neither PKD nor PD independently predicted the mortality.

Conclusion

PD can be an option for ESRD patients with PKD.

Key words: polycystic kidney disease, peritoneal dialysis, hemodialysis, survival analysis

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