间充质干细胞防治病理性瘢痕机制的研究进展

doi:10.3881/j.issn.1000-503X.2017.04.018

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2017, Vol. 39 ›› Issue (4): 573-577.doi: 10.3881/j.issn.1000-503X.2017.04.018

• Orginal Article • Previous Articles Next Articles

Advances in Mechanisms for Prevention and Treatment of Pathological Scars with Mesenchymal Stem Cells

Lijiang YU¹, Xiaojun WANG²(), Xiao LONG²

¹Department of Oral and Maxillofacial Surgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China
²Department of Plastic Surgery, PUMC Hospital,CAMS and PUMC,Beijing 100730,China

Received:2016-04-13 Online:2017-08-10 Published:2017-08-20

Abstract

Abstract:

Pathological scars,including keloids and hypertrophic scars,result from aberrations in the process of physiologic wound healing.An exaggerated inflammatory process is one of the main pathophysiological contributors.Pathological scars may cause pain and pruritis,limit joint mobility,and cause a range of cosmetic deformities that affect the patient’s quality of life.However,the effectiveness of currently available prevention and treatment measures remains unsatisfactory.Mesenchymal stem cells,among their multifunctional roles,have the functions of immunomodulation and promotion of angiogenesis.Thus,they have been proposed to be a major candidate for cell therapy to treat or prevent pathologicalscars.This article reviews the mechanism and potentials of stem cell therapy in the prevention and treatment of pathological scars.

Key words: mesenchymal stem cells, pathological scars, cell therapy, angiogenesis, immunomodulation

CLC Number:

R622+.9

Lijiang YU, Xiaojun WANG, Xiao LONG. Advances in Mechanisms for Prevention and Treatment of Pathological Scars with Mesenchymal Stem Cells[J].Acta Academiae Medicinae Sinica, 2017, 39(4): 573-577.

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