Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2017, Vol. 39 ›› Issue (4): 578-582.doi: 10.3881/j.issn.1000-503X.2017.04.019

• Orginal Article • Previous Articles     Next Articles

Significances of MYD88L265P and CXCR4WHIM Mutations in Waldenstrom Macroglobulinemia

Qi MENG, Xinxin CAO, Jian LI()   

  1. Department of Hematology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China
  • Received:2016-04-29 Online:2017-08-10 Published:2017-08-20


Waldenstrom macroglobulinemia(WM) is a lymphoplasmacytic lymphoma characterized by serum monoclonal IgM immunoglobulin.Recently,the high mutation rates of MYD88L265P and CXCR4WHIM have been documented in WM.Furthermore,MYD88L265P and CXCR4WHIM are related to the response to target drugs.This article reviews the significances of MYD88L265P and CXCR4WHIM in the diagnosis and treatment of WM.

Key words: Waldenstrom macroglobulinemia, MYD88L265P, CXCR4WHIM, gene mutation

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