Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2017, Vol. 39 ›› Issue (5): 682-687.doi: 10.3881/j.issn.1000-503X.2017.05.014

• Orginal Article • Previous Articles     Next Articles

Clinical Values of Combined Diffused Optical Tomography and PET-CT in the Diagnosis of Breast Cancer

Hongyan WANG1, Xiaona JIN2, Yuxin JIANG1(), Zhaohui ZHU2, Ying XU3, Qingli ZHU1, Qing DAI1, Jianchu LI1, Fang LI2, Qiang SUN3   

  1. 1Department of Ultrasound, PUMC Hospital,CAMS and PUMC,Beijing 100730,China
    2Department of Nuclear Medicine,PUMC Hospital,CAMS and PUMC,Beijing 100730,China
    3Department of Breast Surgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China
  • Received:2017-01-11 Online:2017-10-30 Published:2017-10-30
  • Supported by:
    Supported by the National Natural Sciences Foundation of China (81601517,81371557)

Abstract:

Objective To investigate the clinical values of combined diffused optical tomography (DOT) combined positron emission tomography-computed tomography (PET-CT) in the diagnosis of breast cancer. Methods We performed DOT and PET-CT examinations in 38 patients with 40 lesions and compared these images with the pathological results to analyze the sensitivity,specificity,accuracy,positive predictive value,and negative predictive value of these two techniques and their combination.Results The sensitivity,specificity,accuracy,positive predictive value,and negative predictive value in diagnosing breast cancer were 78.26%,76.47%,77.50%,72.22%,and 81.81% for DOT,86.96%,82.35%,85.00%,86.96%,and 82.35% for PET-CT,and 86.96%,94.12%,90.00%,95.23%,and 84.21% for the combination of PET-CT and DOT.Conclusions DOT and PET-CT are both effective diagnostic methods for breast cancer.Combined DOT and PET-CT can improve the diagnostic efficacy in terms of specificity,positive predictive value,and accuracy.

Key words: diffused optical tomography, PET-CT, breast cancer

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