Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2017, Vol. 39 ›› Issue (5): 715-720.doi: 10.3881/j.issn.1000-503X.2017.05.019

• Orginal Article • Previous Articles     Next Articles

Research Advances in the Neuroinflammation in Alzheimer’s Disease

Wenpei MA1, Xuan ZHANG2, Qiong WU3()   

  1. 1Second Hospital College, ,Dalian Medical University,Dalian,Liaoning 116044,China
    2Graduated School, ,Dalian Medical University,Dalian,Liaoning 116044,China
    3Department of Physiology,Dalian Medical University,Dalian,Liaoning 116044,China
  • Received:2016-10-24 Online:2017-10-30 Published:2017-10-30
  • Supported by:
    Supported by the National Natural Sciences Foundation of China(81371223) and the Natural Science of Liaoning Province(2015020672)

Abstract:

Alzheimer’s disease(AD) is a chronic degenerative disease of the nervous system,and the pathological change of AD is the formation of senile plaques containing amyloid β(Aβ) and the neurofibrillary tangles. AD patients and animal models exhibit the over activation of microglia(MG) and astrocytes,causing neuroinflammation,leading to neuron death. Inhibition of MG activity can alleviate Aβ plaques. A growing number of studies have found that neuroinflammation is involved in the development and progression of AD. This article reviews the role of neuroinflammation induced by MG,astrocytes,T lymphocyte,and monocyte-derived macrophages in the mechanism of AD.

Key words: neuroinflammation, Alzheimer’s disease, amyloid β

CLC Number: