Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2018, Vol. 40 ›› Issue (1): 67-71.doi: 10.3881/j.issn.1000-503X.2018.01.010

• Original Articles • Previous Articles     Next Articles

Ultrasound-guided Radiofrequency Ablation for Cervical Lymph Nodes Metastasis from Papillary Thyroid Carcinoma

GUANG Yang, LUO Yukun(), ZHANG Yan, ZHANG Mingbo, LI Nan, ZHANG Ying, TANG Jie   

  1. Department of Ultrasound,Chinese PLA General Hospital,Beijing 100853,China
  • Received:2017-11-08 Online:2018-02-28 Published:2018-03-05
  • Supported by:
    Supported by the National Natural Sciences Foundation of China (81471681),the Beijing National Science Foundation (15G30083) and the Clinical Research Support Foundation of PLA General Hospital (2015PC-TSYS-2022)

Abstract:

Objective To assess the effectiveness and safety of ultrasound-guided percutaneous radiofrequency ablation (RFA) for nonsurgical treatment of metastatic lymph nodes (LNs) in the neck from papillary thyroid carcinoma (PTC). Methods Totally 45 PTC patients who had been treated with total thyroidectomy and radioiodine therapy were enrolled in this retrospective study. A total of 71 metastatic LNs in the neck from PTC were confirmed by percutaneous biopsy. Follow-up consisted of conventional ultrasound,contrast-enhanced ultrasound,and thyroglobulin (Tg) measurement 1,3 and 6 months after RFA and then every 6 months. Results All 45 patients were successfully treated,without immediate or later major complications occurred. During the follow-up [(23±5) months;range:12-30 months)],there was no evidence of recurrence at ablated sites. The mean volume reduction ratio (VRR) was significantly reduced during the follow-up. Significant differences in the VRR were found between every two follow-up visits (P<0.001). Furthermore,46 metastatic LNs (64.8%) completely disappeared and 25 metastatic lymph nodes (35.2%) remained as small scar-like lesions at the last follow-up visit. After RFA,mean serum Tg level decreased from (11.3±6.3)ng/ml (range:0.8-19.4 ng/ml) to (1.3±0.9)ng/ml (range:0.2-3.9 ng/ml) at the last follow-up visit (P<0.001). Conclusion Ultrasound-guided percutaneous RFA is a safe and effective therapy for patients with cervical LNs metastasis from PTC.

Key words: ultrasound, radiofrequency ablation, lymph node, papillary thyroid carcinoma

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