Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2018, Vol. 40 ›› Issue (1): 78-82.doi: 10.3881/j.issn.1000-503X.2018.01.012

• Youth Science Forum • Previous Articles     Next Articles

Statin Therapy Regulates Serum Inflammatory Factors in the Treatment of Abdominal Aortic Aneurysms

LIU Duan, LI Fangda, LIAO Pengzhi, WANG Jing, SHAO Jiang, CHEN Yu, LIU Changwei, LIU Bao, YE Wei, CHEN Yuexin, SONG Xiaojun, ZENG Rong, LIU Zhili, ZHENG Yuehong()   

  1. Department of Vascular Surgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China
  • Received:2017-10-09 Online:2018-02-28 Published:2018-03-05
  • Supported by:
    Supported by the National Natural Sciences Foundation of China (81470586) and the Beijing Natural Science Foundation(7172171)

Abstract:

Objective To assess the effect of statin therapy on serum inflammatory cytokines in patients with abdominal aortic aneurysm (AAA). Methods The clinical data of 126 AAA patients who were hospitalized in the Department of Vascular Surgery,Peking Union Medical College Hospital,from September 2014 to September 2017 were retrospectively analyzed. Patients were divided into treatment group and control group according to whether statins were used or not. The levels of serum lipids and serum inflammatory factors were compared between these two groups.Results There was no significant difference in gender,age,body height,body weight,smoking ratio,and AAA diameter between these two groups (all P>0.05). While the levels of total cholesterol (TC),triglyceride (TG),low-density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) were not significantly different before treatment(all P>0.05),the treatment group had significantly lower TC (t=2.868,P=0.009),TG (t=3.472,P=0.006),and LDL-C (t=3.924,P=0.005) and significantly higher HDL-C level (t=3.322,P=0.007) after treatment. In addition,the concentrations of interleukin(IL) -1β,IL-6,high-sensitivity C-reactive protein(hs-CRP),and tumor necrosis factor-α(TNF-α) were not significantly different between these two groups before treatment (all P>0.05);after treatment,the serum levels of IL-1β and IL-6 in the treatment group were (224.32±78.54)and (116.49±19.64)ng/L,respectively,which were lower than those in the control group [(254.68±96.77)ng/L (t=1.765,P=0.058) and (126.71±23.59)ng/L(t=1.692,P=0.063)],although the differences were not statistically significant. The serum levels of hs-CRP and TNF-α in the treatment group were (6.46±1.24)mg/L and (0.77±0.21)μg/L,respectively,which were significantly lower than those in the control group [(10.93±4.18)mg/L (t=2.007,P=0.012) and (1.28±0.49)μg/L(t=2.144,P=0.016)]. Conclusion Statin treatment reduces the levels of hs-CRP and TNF-α in AAA patients.

Key words: statins, abdominal aortic aneurysm, tumour necrosis factor-α, high-sensitivity C-reactive protein

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