Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2018, Vol. 40 ›› Issue (1): 91-97.doi: 10.3881/j.issn.1000-503X.2018.01.014

• Review Articles • Previous Articles     Next Articles

Contribution of Wnt Signaling Pathway to Embryo Implantation

TANG Yedong, ZHANG Zhenghong, TANG Zonghao, WANG Zhengchao()   

  1. Provincial Key Laboratory for Developmental Biology and Neurosciences,College of Life Sciences,Fujian Normal University,Fuzhou 350007,China
  • Received:2017-04-10 Online:2018-02-28 Published:2018-03-05
  • Supported by:
    Supported by the National Natural Sciences Foundation of China (31271255),the Fujian Provincial Natural Science Foundation (2016J01145),and the Fujian Provincial Science and Technology Project of the Education Department (JAT160118)


The establishment of the endometrial receptive state,the implantation of activated blastocysts,and the decidualization of the uterine stroma are essential conditions for successful implantation in mammals and play decisive roles for subsequent pregnancy outcomes. The Wnt signaling pathway is associated with a variety of key functions such as proliferation,differentiation,apoptosis,and regeneration. During the embryo implantation,the Wnt signaling pathway plays an indispensable role. Studies have shown that the abnormal expression of Wnt signaling pathway can lead to endometriosis,endometrial cancer,and other reproductive diseases that seriously affect human health and quality of life. In this article we summarize the roles of Wnt signaling pathway in the establishment of uterine receptivity,blastocyst activation,embryo implantation,and decidualization and its regulatory mechanisms.

Key words: Wnt signaling pathway, peri-implantation, embryo implantation

CLC Number: