Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2018, Vol. 40 ›› Issue (1): 98-103.doi: 10.3881/j.issn.1000-503X.2018.01.015

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Research Advances in Sex Determining Region Y Box 18 in Tumors

YIN Huaqi, QIN Caipeng, ZHANG Xiaowei, XU Tao()   

  1. Department of Urology,Peking University People’s Hospital,Beijing 100044,China
  • Received:2017-02-27 Online:2018-02-28 Published:2018-03-05
  • Supported by:
    Supported by the National Natural Sciences Foundation of China (31671469)


Sex determining region Y box (SOX) 18 is a member of the SOX family of transcription factors. SOX18 is crucial for cardiogenesis,angiogenesis,and lymphangiogenesis during embryonic development. The mutation or aberrant expression of SOX18 is involved in many diseases. Recently,the abnormal expression of SOX18 has been confirmed to be related with the development and metastasis of various tumors. This article summarizes the functional characteristics of SOX18 and its roles in tumors.

Key words: sex determining region Y box 18, aberrant expression, tumor progression, signal transduction

CLC Number: