Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2018, Vol. 40 ›› Issue (1): 104-111.doi: 10.3881/j.issn.1000-503X.2018.01.016

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Maintaining Cholesterol Homeostasis in Small Intestine for the Prevention of Atherosclerosis

CHEN Xinnong1, GUO Xiaochen2, ZHANG Junping2()   

  1. 1Graduate School,the First Affiliated Hospital, Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China
    2Department of Cardiovascular Disease,the First Affiliated Hospital, Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China
  • Received:2017-01-21 Online:2018-02-28 Published:2018-03-05
  • Supported by:
    Supported by the National Natural Sciences Foundation of China (81403217)

Abstract:

Cholesterol is an important lipid that significantly affects life. High blood cholesterol level can lead to the cholesterol deposition on the intima of large and middle arteries,and the formation of atherosclerotic plaques,which can trigger endothelial injury and lipid infiltration and finally induce atherosclerosis (AS). Up to now R&D of cholesterol-lowering drugs are mainly focused on the the function of liver in cholesterol synthesis. Notably,the small intestine is the major site of cholesterol metabolism and is involved in maintaining the homeostasis of cholesterol. Gut maintains the cholesterol homeostasis through a complex regulatory mechanism that involves different stages including cholesterol absorption,transformation,and excretion as well as lipoprotein synthesis. In this article we summarizes the research advances in the molecular regulation of cholesterol metabolism in small intestine and its relationship with AS,with an attempt to provide a new insight into the diagnosis and treatment of atherosclerotic disease.

Key words: small intestine, cholesterol, atherosclerosis, bile acid, lipoprotein synthesis

CLC Number: