Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2018, Vol. 40 ›› Issue (1): 112-115.doi: 10.3881/j.issn.1000-503X.2018.01.017

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Roles of Autophagy and Apoptosis in Sarcopenia

GONG Ge1, YANG Xiang1, YIN Jian2, ZHANG Xinghu1, ZHANG Yuan1, WAN Wenhui1()   

  1. 1Department of Geriatrics,Nanjing General Hospital of PLA,Nanjing 210002,China
    2Department of Orthopaedics,the Affiliated Jiangning Hospital,Nanjing Medical University,Nanjing 211100,China
  • Received:2017-02-04 Online:2018-02-28 Published:2018-03-05
  • Supported by:
    Supported by the Special Fund for Military Health (13BJZ11),the Nanjing Military Command Medical Research Foundation (11MA101),and the Hospital Project of the Nanjing General Hospital of PLA(2017065)

Abstract:

Sarcopenia is an aged-related progressive and systemic loss of skeletal muscle mass and functions. It may be caused by factors such as exercise,nutrition,genetic factors,endocrine factors,and inflammation. The pathophysiological mechanisms include mitochondrial dysfunction,excessive activation of apoptosis,dysregulation of autophagy,abnormal function of satellite cells,and aggregation of reactive oxygen species. This article summarizes the relationships of autophagy and apoptosis with sarcopenia and discusses the values of autophagy regulation and apoptosis reduction in the management of sarcopenia.

Key words: sarcopenia, pathophysiological mechanisms, autophagy, apoptosis

CLC Number: