Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2018, Vol. 40 ›› Issue (2): 279-283.doi: 10.3881/j.issn.1000-503X.2018.02.020

• Review Articles • Previous Articles     Next Articles

Molecular Mechanisms of Breast Nodule Stiffness

XUE Xiaowei1, LI Junlai1(), WAN Wenbo2, LI Xiankun2   

  1. 1Department of Ultrasound,the Southern Building, Chinese PLA General Hospital,Beijing 100853,China
    2Department of Ultrasound, Chinese PLA General Hospital,Beijing 100853,China
  • Received:2017-11-17 Online:2018-04-28 Published:2018-05-03
  • Supported by:
    Supported by the National Natural Sciences Foundation of China(81771835)


The texture of breast nodules has always the focus of clinical palpation,and the stiffness of breast nodules has been a hot research topic of ultrasound elastography. Both texture and stiffness are based on the principle that malignant tissue is stiffer than benign tissues,but the underlying mechanisms of breast nodule stiffness is not yet confirmed. Breast nodule stiffness is affected by both substance and mesenchyme,and the latter is an important factor. Collagen,as the major composition of the extra cell matrix,plays an important role in breast nodule stiffness. This review summarizes the molecular mechanisms of intracellular and extracellular changes in the formation of breast nodules.

Key words: stiffness, breast nodule, collagen fiber

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