Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2018, Vol. 40 ›› Issue (2): 294-298.doi: 10.3881/j.issn.1000-503X.2018.02.023

• Review Articles • Previous Articles     Next Articles

Regulatory Effects of Erythropoietin-producing Hepatocyte Kinase Receptor and Ephrin Ligand on Bone Remodeling

XU Xiaonan, ZHANG Ding()   

  1. Department of Stomatology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China
  • Received:2017-03-15 Online:2018-04-28 Published:2018-05-03
  • Supported by:
    Supported by the National Nature Sciences Foundation of China(31371389)


During the process of bone remodeling,the bone homeostasis is tightly controlled by the coupling of bone resorption and bone formation,depending upon cellular communication between osteoclasts and osteoblasts. Many studies have identified that the bi-directional transduction of erythropoietin producing hepatocyte kinase receptor and ephrin ligand (Eph/ephrin) is one of signal transduction pathways in bone remodeling. This review focus on the potential role of Eph/ephrin in bone remodeling,especially in alveolar remodeling.

Key words: bone remodeling, alveolar remodeling, erythropoietin-producing hepatocyte kinase receptor, bi-directional transduction

CLC Number: