Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2018, Vol. 40 ›› Issue (3): 338-343.doi: 10.3881/j.issn.1000-503X.2018.03.007

• Original Articles • Previous Articles     Next Articles

Association of Serum Uric Acid Level with Coronary Heart Disease in Men and Women

LI Chenyi(),CHEN Jia,SHI Xiangfan   

  1. Department of Medical Care for Cadres,Zhejiang Hospital,Hangzhou 310012,China
  • Received:2017-07-24 Online:2018-06-30 Published:2018-07-05
  • Supported by:
    Supported by the Medical and Health Science and Technology Program of Zhejiang Province(201346767)

Abstract:

Objective To explore the relationship between serum uric acid (SUA) level and coronary heart disease(CHD) in male and female patients.Methods A total of 760 hospitalized patients undergoing coronary angiography in our department from June 2013 to June 2017 were enrolled. Gensini score was calculated according to the result of coronary angiography,and SUA was tested.Patients were divided according to SUA quartiles. The relationship between SUA level and the prevalence of CHD in male and female patients was analyzed.Results Among females,there was significant difference in SUA level between patients with and without CHD (t=4.415,P=0.000). Univariate logistic regression analysis showed that SUA level was independently associated with CHD (OR=1.32,95%CI:1.12-1.58,P=0.002). The prevalence of CHD was 31.2%,52.6%,47.4%,and 59.7%,respectively,in four quartile groups (χ 2=13.652,P=0.003);in addition,female patients displayed significantly higher prevalence of CHD in the quartile 2 (P=0.007),3(P=0.038),and 4(P=0.000) groups than in quartile 1 group. Among female patients with CHD,there were significant differences in number of target vessels (Z=4.627,P=0.008),number of lesion vessels (χ 2=18.522,P=0.005),and Gensini score (Z=3.683,P=0.029) in four groups. The Gensini scores of coronary artery were significantly higher in the quartile 4 group than in quartile 1 (P=0.012) and 2 (P=0.014) groups. Multiple linear regression analysis showed that there was a dose-response relationship between SUA level and Gensini score (B=1.105,SE=0.365,P=0.003). Among males,however,there was no significant difference in SUA level between patients with and without CHD(t=1.271,P=0.205). The prevalence of CHD in four quartile groups was 77.9%,69.0%,61.7%,and 79.6%,respectively,showing no significant difference(χ 2=4.514,P=0.211).Conclusions SUA is an independent risk fact for female CHD patients. High SUA level is correlated with severity of CHD only in women.

Key words: coronary disease, Gensini score, serum uric acid

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