Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2018, Vol. 40 ›› Issue (3): 378-384.doi: 10.3881/j.issn.1000-503X.2018.03.014

• Original Articles • Previous Articles     Next Articles

Characteristics of High-resolution Ultrasound in the Assessment of Microcalcification of Papillary Thyroid Carcinoma

TIAN Yan1,LU Yao2,ZHAO Yuzhen3,SHI Yanfen4,ZHENG Min3,LI Jianchu1()   

  1. 1 Department of Ultrasound,PUMC Hospital,CAMS and PUMC,Beijing 100730,China
    2 Department of Breast and Thyroid Surgery, China-Japan Friendship Hospital,Beijing 100029,China
    3 Department of Ultrasound, China-Japan Friendship Hospital,Beijing 100029,China
    4 Department of Pathology,China-Japan Friendship Hospital,Beijing 100029,China
  • Received:2017-11-10 Online:2018-06-30 Published:2018-07-05


Objective To investigate the role of 17-MHz high-frequency linear array probe in detecting the microcalcification of papillary thyroid carcinoma (PTC) and its pathological basis.Methods The clinical data of 75 patients with PTC diagnosed by ultrasonography and pathology in China-Japan Friendship Hospital from January 2016 to January 2017 were analyzed. The detection rate of microcalcification was compared between 17-MHz high-frequency ultrasound and conventional ultrasound,and the imaging findings and pathological results were analyzed.Results Among 93 thyroid nodules,the detection rate of PTC microcalcification by 17-MHz ultrasound was 74.2% (69/93),which was significantly higher than that of conventional ultrasound (59.1%,55/93) (χ 2=4.742,P=0.029). The diagnostic sensitivity,specificity,accuracy,positive predictive value,and negative predictive value of the conventional ultrasound and the 17-MHz ultrasound were 73.6% and 98.1%,60.0% and 57.5%,67.7% and 80.6%,70.9% and 75.4%,and 63.1% and 95.8%,respectively. Pathology confirmed the presence of microcalcification at 53 nodules,among which psammoma bodies were found in 10 nodules;in addition,all the psammoma bodies were located in the cell mass,whereas irregular calcium deposits were mainly in proliferated fibrous tissues.Conclusions The 17-MHz high-frequency ultrasound can increase the detection rate of microcalcification in thyroid nodules. The ultrasonic manifestations of microcalcification do not completely correspond to the psammoma bodies found in pathology;rather,they may represent the irregular calcium deposits on fibrous tissues.

Key words: thyroid, high frequency ultrasound, microcalcification, pathology

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