Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2018, Vol. 40 ›› Issue (3): 421-426.doi: 10.3881/j.issn.1000-503X.2018.03.022

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Role of Paradoxical Hypersecretion of Glucagon in the Pathogenesis of Type 2 Diabetes Mellitus

NAN Min,LI Wenhui()   

  1. Department of Endocrinology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China
  • Received:2017-03-13 Online:2018-06-30 Published:2018-07-05


Insulin resistance and insulin deficiency have long been believed to be the two main causes of type 2 diabetes mellitus (T2DM). However,recent studies have shown that paradoxical hypersecretion of glucagon may also contribute the pathogenesis of T2DM. This article reviews the role of paradoxical hypersecretion of glucagon in the pathogenesis of T2DM and the recent advances in relevant treatment options.

Key words: type 2 diabetes mellitus, paradoxical hypersecretion of glucagon, pathogenesis, treatment

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