Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2006, Vol. 28 ›› Issue (6): 745-749.

• Original Articles • Previous Articles     Next Articles

Effect of Hypokalemia on Glucose Metabolism in Primary Hyperaldosteronism

ZHANG Jing, ZENG Zheng-pei, ZHOU Ya-ru, TONG An-li, LU Lin, SONG Ai-ling, YAN Zhao-li,CHEN Shi, LIANG Wei, LI Yu-xiu, QIN Shu-wen   

  1. Department of Endocrinology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China
  • Received:2006-04-28 Revised:1900-01-01 Online:2006-12-30 Published:2006-12-30
  • Contact: ZENG Zheng-pei

Abstract: ABSTRACT:Objective To investigate the effect of potassium deficiency on glucose and insulin meta- bolism in primary hyperaldosteronism, including aldosterone-producing adenoma (APA) and idiopathic hyperaldosteronism (IHA). Methods Totally 178 patients who were diagnosed as primary hyperaldosteronism(103 patients with APA and 75 with IHA) were divided into hypokalemia group and normal potassium group according to their serum potassium levels. All patients received 3 hours of oral glucose tolerance test and aldosterone test to observe the relationship among glucose, insulin and serum potassium. Results Area under curve of serum potassium, area under curve of plasma insulin,and fasting serum insulin were significantly lower in the hypokalemia group than in the normal potassium group(P<0.05,P<0.01); area under curve of glucose and aldosterone level were significantly higher in the hypokalemia group than in the normal potassium group (P<0.05). The prevalence of metabolic syndrome was significantly higher in IHA than in APA (57.3% vs 38.8%; P<0.05). Conclusion Hypokalemia may play an important role in inhibiting insulin secretion in primary hyperaldosteronism.

Key words: dypokalemia, primary dyperaldosteronism, oral clucose tolerance test, metabolic syndrome