Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2006, Vol. 28 ›› Issue (6): 795-798.

• Original Articles • Previous Articles     Next Articles

Quantitative Analysis of Brain Volume by in vivo Magnetic
Resonance Imaging in Normal Adults

ZENG Qing-shi, LI Chuan-fu, LIU Zun-qi, LOU Li, CUI Yi   

  1. Imaging Center, Qilu Hospital, Shandong University, Jinan 250012, China
  • Received:2006-01-20 Revised:1900-01-01 Online:2006-12-30 Published:2006-12-30
  • Contact: ZENG Qing-shi

Abstract: ABSTRACT:Objective To quantify neuroanatomical parameters with magnetic resonance imaging (MRI) and to explore the relationship between these parameters and age. Methods Totally 150 healthy adults aged 18-83 years received 3D fast spoiled gradient echo imaging. Volume of intracranial space, whole brain, gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF) were measured and normalized. Results Normative volumetric estimates were obtained for all subjects and presented by age and sex. There was not significantly age-related change in intracranial space volume. Whole brain volume did not significantly change before 30 years,thereafter,decline with age. GM volume decreased linearly with age. CSF volume increased linearly with age. WM volume and GM/WM ratio demonstrated a quadratic pattern of change with age. WM volume increased slightly in subjects until the age of 45 years,and it decreased thereafter. However,GM/WM ratio decreased quickly in subjects until the age of 55 years,and it decreased slightly thereafter. Although the volumes of intracranial space and whole brain had significant differences between male and female(P<0.05), the volumes of whole brain, GM, and CSF had no significant differences after normalization. Conclusion In vivo MRI can measure the normal patterns of age- and sex-related changes in intracranial space, whole brain, GM, WM, and CSF, and may facilitate the appraisal of abnormal brain volumes.

Key words: brain, volume measurement, macnetic resonance imacinc