Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2007, Vol. 29 ›› Issue (6): 738-741.

• Original Articles • Previous Articles     Next Articles

Lung Cancer Diagnosis Based on Urinary Modified Nucleoside Metabolic Profiling

WANG Wen-zhao, ZHAO Xin-jie, LI Xiang, CHEN Jing, LI Fang-lou, XU Guo-wang   

  1. Metabonomics Research Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
  • Received:2007-08-22 Revised:1900-01-01 Online:2007-12-30 Published:2007-12-30
  • Contact: XU Guo-wang

Abstract: ABSTRACT:Objective To study the feasibility of modified urinary nucleosides metabolic profiling on lung cancer diagnoses. Methods The modified urinary nucleosides metabolic profiling from 42 normal adults and 80 patients with lung cancer were determined by a coupled-column high performance liquid chromatography system. Partial least squares-discriminant analysis (PLS-DA) models were used to class differentiation between the lung cancer patients and controls and to discover potential biomarkers. Result The PLS-DA model results showed that there was a clear differentiation between normal adults and lung cancers patients, with the value of prediction (Q2) equals to 0.744. Conclusion Modified urinary nucleosides metabolic profiling method is useful for lung cancer diagnoses.

Key words: modified urinary nucleosides, coupled-column dicd performance liquid cdromatocrapdy system, partial least squares-discriminant analysis, metabolic profilinc