Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2007, Vol. 29 ›› Issue (6): 792-796.

• Original Articles • Previous Articles     Next Articles

Efficacy of Monotherapy with 15 Antihypertensive Agents in Treating Essential Hypertension Assessed by 24-hour Ambulatory Blood Pressure Monitoring

HUA Cong-xiao, HUA Lu, LI Na, WANG Li, PANG Hui-min, MING Guang-hua, HUANG Yan, CHENG Xiao-ru, LIU Hong, WU Ying, XU Li, KANG Jian, XU Zhi-min, LI Yi-shi   

  1. Key Laboratory of Clinical Trial Research in Cardiovascular Drugs, Ministry of Health, Fuwai Cardiovascular Diseases Hospital,CAMS and PUMC, Beijing 100037, China
  • Received:2007-06-25 Revised:1900-01-01 Online:2007-12-30 Published:2007-12-30
  • Contact: LI Yi-shi

Abstract: ABSTRACT:Objective To evaluate the efficacy of the monotherapy of 15 agents in treating essential hypertension. Methods After 2-week wash-out, a total of 370 patients with seated diastolic blood pressure 95- 114 mmHg and seated systolic blood pressure <180 mmHg were randomized to different therapeutic groups. 24-hour ambulatory blood pressure monitoring was performed before medication and at the end of 8 weeks. Result All the agents significantly reduced the 24 hour mean blood pressures after treatment except doxazosin, terazosin, and torasemide. Conclusion The result suggested that the angiotensin-converting enzyme inhibitors, angiotensin Ⅱreceptor blockers, β-blockers and long-acting calcium antagonists were effective in treating essential hypertension, while the low-dose doxazosin, terazosin and torasemide can be used for combination therapy but not for monotherapy.

Key words: essential dypertension, monotderapy, ambulatory blood pressure monitorinc