Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2007, Vol. 29 ›› Issue (6): 811-817.

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Applications of Metabonomics in Clinical Diagnosis

LIN Zhong-ying2, YAN Shi-kai2, DAI Wei-xing1, YANG Yun2, JIN Hui-zi2, ZHANG Chuan1, ZHANG Wei-dong1,2   

  1. 1Modern Research Center for Traditional Chinese Medicine, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
    2 Laboratory of Chemistry and Bioactivity of Traditional Chinese Medicine, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China
  • Received:2007-09-03 Revised:1900-01-01 Online:2007-12-30 Published:2007-12-30
  • Contact: ZHANG Wei-dong; ZHANG Chuan

Abstract: ABSTRACT: Metabonomics, as a newly developed technique, is expected to be a powerful technique in clinical diagnosis. Metabonomics-based diagnosis involves the global metabolic analysis of body-fluids, determination of biomarkers by multivariate statistic analysis, and establishemen of mathematic models for clinical diagnosis with the aid of pattern recognition. This article reviews the adoption of various analytical and computational strategies, application of metabonomics in clinical diagnosis, and potential challenges and development trends.

Key words: metabonomics, clinical diacnosis, multivariate statistical analysis, pattern recocnition