Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2008, Vol. 30 ›› Issue (3): 334-337.

• Original Articles • Previous Articles     Next Articles

Changes of Serum Gastrin, Plasma Motilin, and Gastric Motility in Gastric Cancer Patients after Subtotal Gastrectomy

ZHANG Qun1, YU Jian-chun1, KANG Wei-ming1, KE Mei-yun2, QIAN Jia-ming2   

  1. 1Department of General Surgery, 2Department of Gastroenterology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China
  • Received:2007-10-15 Revised:1900-01-01 Online:2008-06-30 Published:2008-06-30
  • Contact: YU Jian-chun

Abstract: ABSTRACT:Objective To study the change of the serum gastrin (GAS) and plasma motilin (MTL) levels as well as the gastric motility in gastric cancer patients after subtotal gastrectomy. Methods We used radioimmunoassay method to detect the levels of serum GAS and plasma MTL in 39 healthy volunteers (control group) and 39 gastric cancer patients before and after gastrectomy (gastric cancer group). Electrogastrography (EGG) was measured at the same time points. Results The levels of serum GAS and plasma MTL in gastric cancer group before operation were significantly higher than those in control group (P=0.000), and the levels of serum GAS and plasma MTL in gastric cancer stage Ⅱ patients were also significantly higher than those in stage Ⅲ patients(P<0.05). The levels of serum GAS and plasma MTL in gastric cancer group significantly decreased on the first post-operative day (P=0.000), but returned to the pre-operative levels on the seventh post-operative day. The incidence of the abnormity of gastric motility in gastric cancer group on the seventh post-operative day was significantly higher than the pre-operation incidence ( 89.7% vs. 43.6%; χ2=18.692, P<0.01). Conclusions The levels of serum GAS and plasma MTL transiently decreased in gastric cancer patients. Subtotal gastrectomy could affect the gastric motility in gastric cancer patients.

Key words: castric cancer, castrin, motilin, castric motility, subtotal castrectomy