白介素-1β基因多态性与睡眠呼吸暂停综合征的相关性

doi:10.3881/j.issn.1000-503X.2014.02.006

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2014, Vol. 36 ›› Issue (2): 145-152.doi: 10.3881/j.issn.1000-503X.2014.02.006

• Original Articles • Previous Articles Next Articles

Association of Interleukin-1β Genetic Polymorphisms with Obstructive Sleep Apnea Syndrome

ZHANG Jing-jing¹,LI Nan-fang²,YAO Xiao-guang²,ZHOU Ling²,SHAO Liang²,HONG Jing²,YIN Ting²,KONG Jian-qiong²

¹Medical School of Shihezi University of Xinjiang,Shihezi,Xinjiang 832000,China
²Hypertension Center of People’s Hospital of Xinjiang Uygur Autonomous Region,Hypertension Institute of Xinjiang,Urumqi 830001,China

Received:2013-12-09 Online:2014-04-28 Published:2014-04-28
Contact: LI Nan-fang Tel:0991-8564818,Fax:0991-8561831,E-mail:lnanfang2010@sina.com E-mail:lnanfang2010@sina.com
Supported by:
Supported by the National Natural Sciences Foundation of China(81260017)and the Open Project of Key Labotary of Xinjiang Uygur Autonomous Region(XJYS0906-2011-06)

Abstract

Abstract:

Objective To investigate the association between interleukin(IL)-1β genetic polymorphisms and obstructive sleep apnea syndrome(OSAS).Methods Totally 850 individuals with hypertension were included.All of them were checked by polysomnography in the Hypertension Center of People’s Hospital of Xinjiang Uygur Autonomous Region from January to December in 2010.According to the results of polysomnography,these subjects were divided into non-OSAS group(n=225)and OSAS group(n=625).Genetic variations were sequenced and screened at loci over functional region of IL-1β gene in 96 patients with severe OSAS.The typical loci were selected for genotyping by TaqMan-polymerase chain reaction in 850 subjects.Results One novel and 5 known variations in the IL-1β gene were identified,and then three representative mutation loci were selected for genotyping.The allele frequency distribution of rs1143633 was significantly different between the OSAS and non-OSAS groups in the total and male populations(χ²=9.258,P=0.002;χ²=5.119,P=0.024,respectively).Although the parameters of sleep apnea monitoring showed no significant difference in individuals with CC,CT,and TT genotypes of rs1143633 in total,male,and female populations(P＞0.05),the median of the apnea hypopnea index of CT genotype was significantly higher than that of CC and TT in total and male populations and the mean of the lowest blood oxygen saturation increased in individuals with CC,CT,and TT genotypes of rs1143633 in total and male populations.Haplotype was no significantly associated with OSAS in total,male,and female populations(P＞0.05).Logistic regression analysis showed that CT genotype of rs1143633 variation was a risk factor for OSAS in total and male populations(OR=1.574,95% CI=1.061-2.437,P=0.042;OR=1.887,95% CI=1.091- 3.265,P=0.023).Conclusion The rs1143633 polymorphism in IL-1β gene may be associated with OSAS.

Key words: Key words:interleukin-1&beta, gene, genetic polymorphism, obstructive sleep apnea syndrome

CLC Number:

ZHANG Jing-jing,LI Nan-fang,YAO Xiao-guang,ZHOU Ling,SHAO Liang,HONG Jing,YIN Ting,KONG Jian-qiong. Association of Interleukin-1β Genetic Polymorphisms with Obstructive Sleep Apnea Syndrome[J].Acta Academiae Medicinae Sinica, 2014, 36(2): 145-152.

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