Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2012, Vol. 34 ›› Issue (4): 359-363.doi: 10.3881/j.issn.1000-503X.2012.04.009

• Original Articles • Previous Articles     Next Articles

Correlations of Podocyte Injury with Glucose Regulated Protein 78 Expression and Proteinuria in Patients with Diabetic Nephropathy

LIU Ying-jiu, WEN Yu-bing, TAO Jian-ling, LI Jin-hong, SU Ying,YE Wei, LI Hang, LI Xue-mei, LI Xue-wang   

  1. Department of Nephrology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China
  • Received:2011-09-25 Revised:2012-08-31 Online:2012-08-30 Published:2012-08-30
  • Supported by:

    Supported by the National Natural Sciences Foundation of China (30700373, 81170665) and the Youth Fund of Peking Union Medical College Hospital

Abstract: Objective To explore the podocyte injury in patients with diabetic nephropathy (DN) and analyze its relationship with glucose regulated protein 78 (GRP78) and proteinuria. Methods The clinical data of 48 patients diagnosed as DN by renal biopsy were reviewed. All patients were divided into two groups according to proteinuria (>3.5 g/d, n=31 and 3.5 g/d group was significantly lower than that of urine protein>3.5 g/d group urine protein<3.5 g/d group(P=0.003), and it was negatively correlated with proteinuria (P=0.005). The expressions of synaptopodin and GRP78 in podocytes were also negatively correlated with proteinuria (P=0.004 and P=0.001). Conclusion The podocyte injury is aggravated with increased proteinuria in DN patients, along with the decrease of the adaptive ability of endoplasmic reticulum to stress.

Key words: podocyte, diabetic nephropathy, synaptopodin, glucose regulated protein 78

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