Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2016, Vol. 38 ›› Issue (5): 589-593.doi: 10.3881/j.issn.1000-503X.2016.05.018

• Orginal Article • Previous Articles     Next Articles

Biological Characteristics of Cluster of Differentiation 147 and Its Relationship with Tumour

Cen GAO, Zhao-hui LU, Jie CHEN()   

  1. Department of Pathology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China
  • Received:2015-09-21 Online:2016-10-20 Published:2016-10-10
  • Supported by:
    Supported by the National Natural Sciences Foundation of China (81472326)

Abstract:

Cluster of differentiation 147(CD147)/extracellular matrix metalloproteinase inducer (EMMPRIN) is a widely distributed transmembrane glycoprotein that belongs to the immunoglobulin superfamily and is highly enriched on the surface of malignant tumour cells. A major function of CD147 is to stimulate matrix metalloproteinase production in stromal fibroblasts and endothelial cells. CD147 promotes growth,invasion,metastasis,and glycolysis of malignant cells,induces angiogenesis,multidrug resistance,and anoikis resistance,and inhibits starvation-induced autophagy et al. This review focuses on the structural and biological characteristics of CD147 as well as recent advances in its multiple functions in malignant tumours and underlining mechanisms.

Key words: cluster of differentiation 147/extracellular matrix metalloproteinase inducer, matrix metalloproteinases, biolog-ical characteristics

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