Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2016, Vol. 38 ›› Issue (5): 601-606.doi: 10.3881/j.issn.1000-503X.2016.05.020

• Orginal Article • Previous Articles     Next Articles

Advances in the Relationship between Adipokines and β-cell Failure in Type 2 Diabetes Mellitus

Qing SUN, Xiao-chun LIANG()   

  1. Department of Traditional Chinese Medicine,PUMC Hospital, CAMS and PUMC,Beijing 100730,China
  • Received:2015-09-06 Online:2016-10-20 Published:2016-10-10
  • Supported by:
    Supported by the Youth Science Foundation of Peking Union Medical College Hospital(pumch-2013-140)


β-cell failure coupled with insulin resistance plays a key role in the development of type 2 diabetes mellitus (T2DM). Changed adipokines in circulating level form a remarkable link between obesity and both β-cell failure and insulin resistance. Some adipokines have beneficial effects,whereas others have detrimental properties. The overall contribution of adipokines to β-cell failure mainly depends on the interactions among adipokines. This article reviews the role of individual adipokines such as leptin,adiponectin,and resistin in the function,proliferation,death,and failure of β-cells. Future studies focusing on the combined effects of adipokines on β-cells failure may provide new insights in the treatment of T2DM.

Key words: adipokines, type 2 diabetes mellitus, β, -cell failure

CLC Number: