Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2019, Vol. 41 ›› Issue (1): 118-123.doi: 10.3881/j.issn.1000-503X.10396

• Review Articles • Previous Articles     Next Articles

Research Advances in Mitogen-activated Protein Kinases in Central and Peripheral Sensitization of Diabetic Neuropathic Pain

ZHANG Xin,SHEN Le,HUANG Yuguang()   

  1. Department of Anesthesiology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China
  • Received:2018-03-16 Online:2019-02-28 Published:2019-03-06
  • Contact: Yuguang HUANG
  • Supported by:
    Supported by the National Natural Sciences Foundation of China(81671098)


Mitogen-activated protein kinases(MAPKs)are Ser/Thr kinases consisting of extracellular regulated protein kinases(ERK)1/2,c-Jun N-terminal kinase 1/2/3,p38 isoforms(α,β,γ,and δ),and ERK5,which mediate a range of cellular activities including proliferation,differentiation,apoptosis,immunity,and inflammation. Pain sensitization is a remodeling mechanism of central and peripheral nociceptor. A growing number of evidences have indicated that MAPKs are extensively activated in the spinal dorsal cord and dorsal root ganglions in the animal models of diabetic neuropathic pain(DNP)and play an important role in the central and peripheral sensitization of DNP. In addition,some drugs can alleviate DNP by suppressing MAPKs activation of central and peripheral nervous system. This article summarizes the research progress of MAPKs in central and peripheral sensitization of DNP.

Key words: mitogen-activated protein kinases, diabetic neuropathic pain, central sensitization, peripheral sensitization, spinal cord, dorsal root ganglion

CLC Number: