Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2006, Vol. 28 ›› Issue (2): 256-261.

• Original Articles • Previous Articles     Next Articles

Profiles of Irregular Bleeding Induced by Low-dose Hormone Therapy and Chinese Formulated Herbs Products

WANG Shao-hai,LIN Shou-qing,GUI Qi-fang,JIN Min-juan,JIANG Ying   

  1. Department of Obstetrics and Gynecology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China
  • Received:2005-04-08 Online:2006-04-30 Published:2006-04-30
  • Contact: LIN Shou-qing

Abstract: ABSTRACT:Objective To compare profiles and related factors of irregular bleeding induced by diffe- rent types of low-dose hormone therapy (HT) and a Chinese formulated herbs products. Methods Applied with open-labeled,randomized,and clinical trial design,136 postmenopausal women were assigned into four groups:group A:estradiol valerate (E2V) 1 mg/d+medroxyprogesterone acetate (MPA) 2 mg/d; group B:conjugated equine estrogen 0.45 mg/d+MPA 2 mg/d; group C:tibolone 1.25 mg/d; group D:a Chinese formulated herbs product (Kuntai) 4# tid. Each subject took element calcium 400 mg/d and vitamin D 200 IU/d concomitantly. Modified Kupperman scores were assessed on baseline and every 3 months thereafter and irregular bleeding was recorded on menopausal diary every day. The duration of this study was 1 year. Results The efficacies were similar in three HT-managed groups,but was better than in group D,although the latter was also effective in alleviating menopausal symptoms. Hazard ratio (HR) of irregular bleeding was 1.00 in group C,2.43 in group A(95% CI:1.08-5.46),3.12 in group B(95% CI:1.42-6.88),and 0.73 in group D(95% CI:0.26-2.04). Most cases initiatially experienced bleeding in the first 3 months but such initiation was a bit later in group C. Endometrium,as detected by B-mode ultrasound,increased approximately 1 mm in HT groups,while it was a bit thicker in group C. Long periods in reproductive age and short time since menopause were high risk factors for irregular bleeding. Conclusion Profiles of irregular bleeding in 3 commonly used types of low-dose HT are different and some factors such as long period in reproductive age and short time since menopause may contribute to bleeding initiation.

Key words: low-dose dormone tderapy, vacinal bleedinc, estradiol valerate, conjucated equine estrocen, tibolone, cdinese formulated medicine Kuntai