Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2006, Vol. 28 ›› Issue (6): 750-755.

• Original Articles • Previous Articles     Next Articles

Characteristics of the Populations Defined by Different
Criteria of the Metabolism Syndrome

GU Wei-qiong, HONG Jie, ZHANG Yi-fei, GUI Ming-hui, XU Min, SHEN Chun-fang, WANG Wei-qing, NING Guang, CHEN Ming-dao   

  1. Shanghai Institute of Endocrine and Metabolic Diseases,Department of Endocrinology, Rui-Jin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
  • Received:2006-06-06 Revised:1900-01-01 Online:2006-12-30 Published:2006-12-30
  • Contact: CHEN Ming-dao

Abstract: ABSTRACT:Objective To compare the characteristics of over weight and obesity subjects defined by three criteria:World Health Organization (WHO) in 1999, the National Cholesterol Education Program Adult Treatment Panel Ⅲ(NCEP-ATPⅢ) in 2001, and the International Diabetes Federation (IDF) in 2005. Methods Medical history collection, physical examination, oral glucose tolerance test (OGTT), and frequently sampled intravenous glucose tolerance test (FSIGTT) were performed in 371 subjects with body mass index (BMI)≥23 kg/m2. Fasting blood samples were taken to test lipid profiles,urea acid level and so on. Data was analyzed including comparison and relationship statistics. Results Data from FSIGTT showed that insulin resistance existed in all over weight and obesity subjects. The relationship between waist and sensitivity index (SI) was superior than that between BMI and SI (r=-0.198 and r=-0.194, P<0.001=. Totally 107 subjects (28.8%) did not meet any definitions, 187 (50.4%) met ATP definition, 98(26.4%) met WHO definition, and 234 (63.1%) met IDF definition. ATP and IDF definitions had the highest coincidence rate (70.3%), and subjects in these two groups almost had basically the same manifestations. The age of onset in WHO group was higher than those in other two groups. Meanwhile, subjects in the WHO group was cha- racterized by lower BMI, higher hyperlipidemia, and significantly increased fasting and postprandial blood glucose level. The MS component scores were positively correlated with age, BMI, waist, and waist-to-hip ratio (WHR), and were negatively correlated with SI. However, no correlation was found between MS component scores and gender, fat%, or acute insulin response to glucose index. Conclusions Some of over weight and obesity subjects only have insulin resistance and have no metabolism syndrome. The group defined by IDF criteria of the metabolic syndrome (MS) has the highest incidence rate. Limited by the requirements of insulin resistance evaluation, the definition proposed by WHO is somewhat unfeasible for practices. ATP definition may be replaced by IDF definition, because the populations defined by ATP definition is covered by the latter. Meanwhile, the abnormalities of fat mass distribution in the body (i.e., central obesity), rather than its contents, may exacerbate the occurrence of MS, as well as the development of insulin resistance.

Key words: metabolic syndrome, insulin resistance, obesity