中国医学科学院学报

高级检索
中国医学科学院学报

中国医学科学院学报 ›› 2008, Vol. 30 ›› Issue (5): 535-539.doi: 10.3881/j.issn.1000-503X.2008.05.005

• 论著 • 上一篇    下一篇

一起医院内群体性诺如病毒急性胃肠炎的调查

徐 潜1,郎琳娜1,张 璟1,钱 渊2,贾立平2,张 政3,王勤环4   

  1. 1卫生部中日友好医院感染疾病科,北京100029
    2首都儿科研究所病毒室,北京 100020
    3北京市朝阳区疾病预防控制中心,北京 100021
    4北京大学 第一医院感染疾病科,北京 100034
  • 收稿日期:2008-04-03 修回日期:1900-01-01 出版日期:2008-10-30 发布日期:2008-10-30
  • 通讯作者: 徐潜

An Acute Norovirus Gastroenteritis Outbreak in A Hospital

XU Qian1,LANG Lin-na1,ZHANG Jing1,QIAN Yuan2,JIA Li-ping2,ZHANG Zheng3,WANG Qin-huan4   

  1. 1 Department of Infectious Diseases, China-Japan Friendship Hospital,Beijing 100029,China
    2Department of Virus,Capital Institute of Pediatrics, Beijing 100020,China
    3Chaoyang Centers for Diseases Control and Prevention,Beijing 100021,China
    4 Department of Infectious Diseases, Peking University First Hospital,Beijing 100034,China
  • Received:2008-04-03 Revised:1900-01-01 Online:2008-10-30 Published:2008-10-30
  • Contact: XU Qian

摘要: 摘要:目的 对一起发生在北京市某医院的群体性诺如病毒急性肠胃炎进行调查和分析。方法 采用现场流行病学方法进行调查,PCR检测患者粪便标本,Western blot检测患者血清抗体。结果 本次疫情流行26d,共发病87例,其中住院患者65例,医护人员15例,陪护人员6例,配餐员1例。PCR检查示20例患者粪便标本中,12例诺如病毒核酸检测为阳性。Western blot检测示24例患者血标本中,19例诺如病毒抗体为强阳性。通过隔离治疗患者、加强消毒和卫生宣教等综合措施,疫情得到有效控制。结论 本次急性胃肠炎暴发疫情由诺如病毒引起,感染来源尚不明确。

关键词: 诺如病毒, 急性胃肠炎, 医院感染

Abstract: ABSTRACT:Objective To investigate and analyze a case of acute norovirus gastroenteritis outbreak in a hospital. Methods Data were collected through the on-the-spot investigation and faecal specimens were tested by polymerase chain reaction-reverse transcription (RT-PCR). Serum specimens were tested by Western blot. Results The outbreak lasted 26 days. A total of 87 cases were reported, including 65 inpatients, 15 health-care workers, 6 accompanies, and 1 pantryman. Twelve (60%) of 20 stool specimens were norovirus-positive by RT-PCR and 19 of 24 blood samples were norovirus-positive by Western blot. The outbreak was effectively controlled by isolating and treating the patients, extensive disinfection, and health education. Conclusion The gastroenteritis outbreak was caused by norovirus with unkown infection source.

Key words: norovirus, acute castroenteritis, nosocomial infection