中国医学科学院学报

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中国医学科学院学报

中国医学科学院学报 ›› 2008, Vol. 30 ›› Issue (6): 651-654.doi: 10.3881/j.issn.1000-503X.2008.06.005

• 论著 • 上一篇    下一篇

梅尼埃病的内淋巴显像

刘芳;黄魏宁;宋海涛;张秋颖   

  1. 卫生部北京医院耳鼻咽喉科,北京100730
  • 收稿日期:2008-09-04 修回日期:1900-01-01 出版日期:2008-12-30 发布日期:2008-12-30
  • 通讯作者: 黄魏宁

Endolymphatic Visualization in Patients with Meniere’s Disease

LIU Fang;HUANG Wei-ning; SONG Hai-tao;ZHANG Qiu-ying   

  1. Department of Otolaryngology, Beijing Hospital, Beijing 100730, China
  • Received:2008-09-04 Revised:1900-01-01 Online:2008-12-30 Published:2008-12-30
  • Contact: HUANG Wei-ning

摘要: 摘要:目的 运用无创性的经咽鼓管鼓室内导入造影剂钆技术,进行内耳三维快速液体衰减反转恢复核磁共振 (3D-FLAIR MRI)扫描,探讨梅尼埃病内淋巴显像的可行性。方法 2例顽固性、活动性梅尼埃病患者经咽鼓管鼓室内导入钆喷酸葡胺稀释液24h后进行内耳3D-FLAIR MRI。患者行钆喷酸葡胺溶液导入前、后24h分别进行纯音测听和鼓室导抗检查。结果 内耳3D-FLAIR MRI显示造影剂钆可以分布到内耳外淋巴,并且可以区分内、外淋巴间隙的边界,清晰显像内淋巴情况;2例患者造影前、后24h纯音测听平均听阈值和鼓室导抗无变化。结论 运用内耳3D-FLAIR MRI加咽鼓管鼓室内导入造影剂钆,可以显像梅尼埃病内淋巴情况;经咽鼓管鼓室内导入造影剂是安全、有效的给药新途径。

关键词: 梅尼埃病, 内淋巴显像, 三维快速液体衰减反转恢复核磁共振, 经咽鼓管给药

Abstract: ABSTRACT:Objective To attempt to visualize the endolymph in patients with Meniere’s disease by applying non-invasive intratympanic gadolinium through eustachian tube and three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging (3D-FLAIR MRI). Methods With a 3 Tesla magnetic resonance imaging (MRI) unit, 3D-FLAIR imaging was performed 24 hours after intratympanic gadolinium through eustachian tube in two patients with medically active and intractable Meniere’s disease. Pure tone test and tympanometry were performed 24 hours before and after the administration of gadolinium. Results The gadolinium appeared in almost all parts of the perilymph inside the inner ear; moreover, the border between the perilymph and the endolymph was visible so endolymphatic space was clearly shown on 3D-FLAIR. No change in pure tone test and tympanometry was noted. Conclusions 3D-FLAIR MRI with intratympanic gadolinium through eustachian tube can clearly reveal the visualization of endolymph in patients with Meniere’s disease. Intratympanic gadolinium therapy through eustachian tube is a safe and effective.

Key words: meniere’s disease, endolympdatic visualization, tdree-dimensional fluid-attenuated inversion recovery macnetic resonance imacinc, administration tdroucd eustacdian tube