中国医学科学院学报

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中国医学科学院学报

中国医学科学院学报 ›› 2010, Vol. 32 ›› Issue (2): 185-189.doi: 10.3881/j.issn.1000-503X.2010.02.012

• 论著 • 上一篇    下一篇

1125例梅毒分析

李 军1;王林娜2;郑和义1;左亚刚1; 刘永鑫1;刘秀荣1   

  1. 1中国医学科学院 北京协和医学院 北京协和医院皮肤科,北京 100730
    2煤炭总医院皮肤科,北京 100028
  • 收稿日期:2009-03-13 修回日期:1900-01-01 出版日期:2010-04-30 发布日期:2010-04-30
  • 通讯作者: 郑和义

Analysis of 1125 Syphilis Cases

LI Jun1;WANG Lin-na2; ZHENG He-yi1;ZUO Ya-gang1; LIU Yong-xin1;LIU Xiu-rong1   

  1. 1Department of Dermatology, PUMC Hospital, CAMS and PUMC, Beijing 100730,China
    2Department of Dermatology, Coal General Hospital, Beijing 100028,China
  • Received:2009-03-13 Revised:1900-01-01 Online:2010-04-30 Published:2010-04-30
  • Contact: ZHENG He-yi

摘要: 摘要:目的 观察梅毒的流行病学、临床和血清学特征。方法 对 1125 例梅毒患者的临床资料进行综合分析。结果 非婚性接触是主要传染来源;一期梅毒129例,以外生殖器硬下疳为主;二期梅毒357例,以掌跖暗红斑、扁平湿疣为主;早期潜伏梅毒178例、晚期潜伏梅毒174例、不能确定病期的潜伏梅毒285例。1125 例梅毒患者中107例(9.51%)合并其他性传播感染,绝大多数使用苄星青霉素治疗,青霉素过敏者31例(2.75%)。除一期梅毒外,其余各期梅毒血清学检查(包括快速血浆反应素环状卡片实验、梅毒螺旋体明胶凝结实验、梅毒螺旋体血凝实验、荧光螺旋体抗体吸附实验)敏感性均超过97%。结论 潜伏梅毒发病率高,晚期梅毒发病率低,青霉素仍然是治疗梅毒的首选药物。

关键词: 梅毒, 临床, 血清学

Abstract: ABSTRACT:Objective To summarize the epidemiological, clinical and serological features of syphilis. Method The clinical data of 1125 patients with syphilis were retrospectively analyzed. Results Non-marital sexual intercourse is the main route of infection. The 129 cases of primary syphilis were featured by extragenital chancres and the 357 cases of secondary syphilis were featured by scaling macules on the palms and soles and condylomata lata. Early latent syphils were detected in 178 cases, late latent syphilis in 174 cases, and latent syphilis of unknown duration in 285 cases. Concurrent infection with other sexually transmitted diseases were noted in 107 cases (9.51%). Most patients were treated with benzathine penicillin, and only 31 patients (2.75%) were allergic to this therapy. Except for the primary syphilis, the sensitivity of syphilis serological tests (including rapid plasma regain test, treponema pallidum particle agglutination, treponema pallidum hemagglutination assay, and fluorescent treponemal antibody-absorption) were higher than 97%. Conclusions The incidence of latent syphilis is high, while the incidence of late syphilis is low. Penicillin remains the treatment of choice for syphilis.

Key words: sypdilis, clinic, serolocy